CJC-1295 without DAC is a synthetic peptide developed as a derivative of natural growth hormone-releasing hormone (GHRH). This peptide consists of 29 amino acids and is also known as Mod GRF (1-29). It was designed to retain the properties of natural GHRH while being more stable in research settings.
How does CJC-1295 without DAC work, according to research?
CJC-1295 without DAC is designed to bind to the GHRH receptor in the pituitary gland, the gland responsible for growth hormone secretion. Researchers hypothesize that this binding can trigger a series of cellular signals that ultimately lead to the production and release of growth hormone (GH).
Structural modifications to the peptide
CJC-1295 without DAC differs from the native GRF fragment by four specific amino acid changes designed to improve stability and biological activity:
- Position 2: Replacement of L-alanine with D-alanine to slow degradation
- Position 8: Replacement of asparagine with glutamine to reduce chemical instability
- Position 15: Replacement of glycine with alanine to support bioactivity
- Position 27: Replacement of methionine with leucine to reduce oxidation
Research on growth hormone and IGF-1
Experimental studies reported an increase in average growth hormone secretion by approximately 70–107% over 12 hours, an increase in IGF-1 levels by approximately 28%, indications of increased skin cell activity, and increases in muscle tissue hypertrophy and muscle mass.
Combination research with other peptides
A frequently studied combination is with Ipamorelin. Both peptides stimulate the pituitary gland via different mechanisms, leading researchers to hypothesize a possible synergistic effect on growth hormone secretion.
